MolNFT v1 · #165034 · protein
Crystal structure of human sugar transporter GLUT1 (SLC2A1) in the inward conformation
6THA · Solute carrier family 2, facilitated glucose transporter…: “Crystal structure of human sugar transporter GLUT1 (SLC2A1) in the inward conformation”. X-ray diffraction, 2 ligands (BNG, CL), 4 pockets (best druggability 0.78). MolNFT…
- PDB
- 6THA
- Type
- protein
- Length
- 448 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Solute carrier family 2, facilitated glucose transporter member 1
- UniProt
- P11166
- Ligands
- BNG, CL
- Pockets
- 4 · best druggability 0.78
Structure
x-ray diffraction · 1 distinct chain · 80% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Solute carrier family 2, facilitated glucose transporter member 1 | protein | 448 | 80% helix, 0% strand | P11166 |
Ligands and binding sites
- BNG · nonyl beta-D-glucopyranoside · ligand · 2 copies · chains A
- CL · Chloride ion · ion · chains A
- P33 · 3,6,9,12,15,18-hexaoxaicosane-1,20-diol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1133 | 0.78 | 0.79 | 84 | BNG, P33 |
| 2 | 54 | 0.35 | 0.78 | 12 | empty |
| 3 | 50 | 0.33 | 0.77 | 10 | empty |
| 4 | 55 | 0.28 | 0.74 | 16 | empty |
Compared structures
- 6THA · Crystal structure of human sugar transporter GLUT1 (SLC2A1) in the inward conformation · the same entry in another collection · chain A against A, TM-score 1.00
- P11166 · AlphaFold monomer V2.0 prediction for solute carrier family 2, facilitated glucose… · a predicted model of the same protein · chain A against A, TM-score 0.86
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P11166
- Elsewhere: RCSB PDB 6THA · PDBe 6THA · UniProt P11166
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