MolNFT v1 · #164982 · protein
FRIZZLED8 crd
6TFM · Frizzled-8: “FRIZZLED8 crd”. X-ray diffraction, 8 pockets (best druggability 0.77). MolNFT v1 #164982 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6TFM
- Type
- protein
- Length
- 513 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Frizzled-8
- UniProt
- Q61091
- Pockets
- 8 · best druggability 0.77
Structure
x-ray diffraction · 3 distinct chains · 41% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Frizzled-8 | protein | 129 | 40% helix, 14% strand | Q61091 |
| D | Frizzled-8 | protein | 127 | 41% helix, 13% strand | Q61091 |
| C | Frizzled-8 | protein | 128 | 41% helix, 13% strand | Q61091 |
Pockets
8 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 909 | 0.77 | 0.80 | 101 | empty |
| 2 | 230 | 0.48 | 0.74 | 30 | empty |
| 3 | 90 | 0.42 | 0.78 | 21 | empty |
| 4 | 132 | 0.40 | 0.75 | 20 | empty |
| 5 | 93 | 0.36 | 0.74 | 14 | empty |
Interfaces
4 interfaces between chains.
- A–C · 488 Ų buried · 8 hydrogen bonds · protein-protein
- D–B · 441 Ų buried · 6 hydrogen bonds · protein-protein
- B–C · 252 Ų buried · 4 hydrogen bonds · protein-protein
- D–C · 107 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 20 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q61091
- Elsewhere: RCSB PDB 6TFM · PDBe 6TFM · UniProt Q61091
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