Crystal structure of the BCL6 btb domain in complex with a hybrid btb- binding (hbp) peptide

Structure

x-ray diffraction · 3 distinct chains · 51% helix, 19% strand (DSSP).

Ligands and binding sites

• NA · Sodium ion · metal · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Interfaces

5 interfaces between chains.

• A–B · 2003 Ų buried · 33 hydrogen bonds · protein-protein
• A–D · 898 Ų buried · 17 hydrogen bonds · protein-protein
• B–C · 800 Ų buried · 15 hydrogen bonds · protein-protein
• B–D · 468 Ų buried · 2 hydrogen bonds · protein-protein
• A–C · 390 Ų buried · 2 hydrogen bonds · protein-protein

Compared structures

• 6TCJ · Crystal structure of the BCL6 BTB domain in complex with a hybrid BTB-binding (HBP)… · the same entry in another collection · chain A against A, TM-score 1.00
• P41182 · AlphaFold monomer V2.0 prediction for B-cell lymphoma 6 protein (P41182) · a predicted model of the same protein · chain A against A, TM-score 0.33

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P41182
• Elsewhere: RCSB PDB 6TCJ · PDBe 6TCJ · UniProt P41182