Research workbench
Crystal structure of the BCL6 btb domain in complex with a hybrid btb- binding (hbp) peptide
Analyse Crystal structure of the BCL6 btb domain in complex with a hybrid btb- binding… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6TCJ
- Type
- protein
- Length
- 280 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- B-cell lymphoma 6 protein; Hybrid btb-binding (hbp) peptide
- UniProt
- P41182
- Ligands
- NA
- Pockets
- 1 · best druggability 0.36
Structure
x-ray diffraction · 3 distinct chains · 51% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | B-cell lymphoma 6 protein | protein | 124 | 55% helix, 18% strand | P41182 |
| B | B-cell lymphoma 6 protein | protein | 122 | 53% helix, 18% strand | P41182 |
| C, D | Hybrid btb-binding (hbp) peptide | protein | 17 | 0% helix, 29% strand | — |
Ligands and binding sites
- NA · Sodium ion · metal · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 85 | 0.36 | 0.76 | 16 | empty |
Interfaces
5 interfaces between chains.
- A–B · 2003 Ų buried · 33 hydrogen bonds · protein-protein
- A–D · 898 Ų buried · 17 hydrogen bonds · protein-protein
- B–C · 800 Ų buried · 15 hydrogen bonds · protein-protein
- B–D · 468 Ų buried · 2 hydrogen bonds · protein-protein
- A–C · 390 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 6TCJ · Crystal structure of the BCL6 BTB domain in complex with a hybrid BTB-binding (HBP)… · the same entry in another collection · chain A against A, TM-score 1.00
- P41182 · AlphaFold monomer V2.0 prediction for B-cell lymphoma 6 protein (P41182) · a predicted model of the same protein · chain A against A, TM-score 0.33
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P41182
- Elsewhere: RCSB PDB 6TCJ · PDBe 6TCJ · UniProt P41182
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.