MolNFT v1 · #164830 · protein

Structure of the two-fold capsomer of the DARC1 capsid

6TAS · Activity-regulated cytoskeleton associated protein 1: “Structure of the two-fold capsomer of the DARC1 capsid”. Electron microscopy, 1 ligand (ZN), 18 pockets (best druggability 0.73). MolNFT v1 #164830 on GenesisL1: 3D structure…

PDB: 6TAS
Type: protein
Length: 1,044 residues
Chains: 8
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Activity-regulated cytoskeleton associated protein 1
UniProt: Q7K1U0
Ligands: ZN
Pockets: 18 · best druggability 0.73

Structure

electron microscopy · 4 distinct chains · 52% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, D	Activity-regulated cytoskeleton associated protein 1	protein	164	54% helix, 1% strand	Q7K1U0
B, E	Activity-regulated cytoskeleton associated protein 1	protein	165	57% helix, 0% strand	Q7K1U0
C, F	Activity-regulated cytoskeleton associated protein 1	protein	166	53% helix, 1% strand	Q7K1U0
G, H	Activity-regulated cytoskeleton associated protein 1	protein	27	15% helix, 0% strand	Q7K1U0

Ligands and binding sites

ZN · Zinc ion · metal · 2 copies · chains G, H

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

18 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1199	0.73	0.76	106	empty
2	1023	0.72	0.76	85	empty
3	711	0.69	0.77	72	empty
4	671	0.68	0.77	80	empty
5	582	0.66	0.76	75	empty

Interfaces

14 interfaces between chains.

E–F · 901 Å² buried · 4 hydrogen bonds · protein-protein
B–C · 891 Å² buried · 4 hydrogen bonds · protein-protein
C–D · 847 Å² buried · 3 hydrogen bonds · protein-protein
A–F · 847 Å² buried · 3 hydrogen bonds · protein-protein
D–E · 811 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

6TAS · Structure of the two-fold capsomer of the dArc1 capsid · the same entry in another collection · chain H against H, TM-score 1.00
Q7K1U0 · AlphaFold monomer V2.0 prediction for activity-regulated cytoskeleton associated protein… · a predicted model of the same protein · chain A against A, TM-score 0.89

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q7K1U0
Elsewhere: RCSB PDB 6TAS · PDBe 6TAS · UniProt Q7K1U0

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