MolNFT v1 · #164815 · protein

Crystal structure of the epimerization domain from the third module of tyrocidine synthetase B, TYCB3(E)

6TA8 · Tyrocidine synthase 2: “Crystal structure of the epimerization domain from the third module of tyrocidine synthetase B, TYCB3(E)”. X-ray diffraction, 9 pockets (best druggability 0.83). MolNFT v1 #164815 on GenesisL1: 3D structure…

PDB: 6TA8
Type: protein
Length: 887 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tyrocidine synthase 2
EC: 5.1.1.11
UniProt: O30408
Pockets: 9 · best druggability 0.83

Structure

x-ray diffraction · 2 distinct chains · 38% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tyrocidine synthase 2 (EC 5.1.1.11)	protein	438	38% helix, 22% strand	O30408
B	Tyrocidine synthase 2 (EC 5.1.1.11)	protein	449	38% helix, 22% strand	O30408

Pockets

9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	899	0.83	0.85	83	empty
2	640	0.79	0.84	61	empty
3	53	0.71	0.98	16	empty
4	288	0.60	0.79	27	empty
5	124	0.50	0.80	15	empty

Interfaces

1 interface between chains.

A–B · 334 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

6TA8 · Crystal structure of the epimerization domain from the third module of tyrocidine… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O30408
Elsewhere: RCSB PDB 6TA8 · PDBe 6TA8 · UniProt O30408

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