MolNFT v1 · #164651 · protein

3C-like protease from southampton virus complexed with FMOPL000013A.

6T4S · Genome polyprotein: “3C-like protease from southampton virus complexed with FMOPL000013A.”. X-ray diffraction, 1 ligand (K2P), 2 pockets (best druggability 0.42). MolNFT v1 #164651 on GenesisL1: 3D structure, binding sites and…

PDB: 6T4S
Type: protein
Length: 343 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Genome polyprotein
EC: 3.6.1.15, 3.4.22.66, 2.7.7.48
UniProt: Q04544
Ligands: K2P
Pockets: 2 · best druggability 0.42

Structure

x-ray diffraction · 2 distinct chains · 7% helix, 48% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Genome polyprotein (EC 3.6.1.15, 3.4.22.66, 2.7.7.48)	protein	172	8% helix, 49% strand	Q04544
B	Genome polyprotein (EC 3.6.1.15, 3.4.22.66, 2.7.7.48)	protein	171	7% helix, 48% strand	Q04544

Ligands and binding sites

K2P · 2-(trifluoromethoxy)benzoic acid · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	112	0.42	0.77	30	empty
2	110	0.41	0.77	22	empty

Interfaces

1 interface between chains.

A–B · 902 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

6T4S · 3C-like protease from Southampton virus complexed with FMOPL000013a. · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q04544
Elsewhere: RCSB PDB 6T4S · PDBe 6T4S · UniProt Q04544

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.