UniProt Q04544
Genome polyprotein (Q04544)
Genome polyprotein (UniProt Q04544), EC 2.7.7.48, 3.4.22.66: 30 experimental structures on GenesisL1, 20 ligands bound, 17 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q04544
- Protein
- Genome polyprotein
- EC
- 2.7.7.48, 3.4.22.66, 3.6.1.15
- Experimental structures
- 30
- Predicted models
- 0
- Ligands
- 20
- Pockets
- 17 · 0 records with a druggable one
Structures
30 records of Q04544 in the MolNFT archive: 30 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2IPH | X-ray Structure at 1.75 A Resolution of a Norovirus Protease Linked to an Active Site Directed… | x-ray diffraction | A, B | — | — |
| 2IPH | X-ray structure at 1.75 a resolution of a norovirus protease linked to an active site directed… | x-ray diffraction | A, B | — | — |
| 6T1Q | 3C-like protease from southampton norovirus. | x-ray diffraction | A, B | — | — |
| 6T2I | 3C-like protease from southampton virus complexed with FMOPL000157A. | x-ray diffraction | A, B | JFM | — |
| 6T2X | 3C-like protease from Southampton virus complexed with FMOPL000004a. | x-ray diffraction | A, B | PO4, JFJ | — |
| 6T2X | 3C-like protease from southampton virus complexed with FMOPL000004A. | x-ray diffraction | A, B | PO4, JFJ | — |
| 6T3G | 3C-like protease from southampton virus complexed with FMOPL000324A. | x-ray diffraction | A, B | JOV, PO4 | — |
| 6T49 | 3C-like protease from southampton virus complexed with FMOPL000582A. | x-ray diffraction | A, B | MH5, PO4 | — |
| 6T4E | Native C3-like protease from Southampton virus complexed with FMOPL000287a. | x-ray diffraction | A, B | HWH | 2 (best 0.39) |
| 6T4E | Native C3-like protease from southampton virus complexed with FMOPL000287A. | x-ray diffraction | A, B | HWH | — |
| 6T4S | 3C-like protease from southampton virus complexed with FMOPL000013A. | x-ray diffraction | A, B | K2P | — |
| 6T5D | 3C-like protease from southampton virus complexed with FMOPL000014A. | x-ray diffraction | A, B | MJW | — |
| 6T5R | 3C-like protease from southampton virus complexed with FMOPL000091A. | x-ray diffraction | A, B | PO4, MKN | — |
| 6T6W | 3C-like protease from southampton virus complexed with XST00000692B. | x-ray diffraction | A, B | JL7, PO4 | — |
| 6T71 | 3C-like protease from southampton virus complexed with XST00000375B. | x-ray diffraction | A, B | MQB, PO4 | — |
| 6T82 | 3C-like protease from Southampton virus complexed with FMOPL000542a. | x-ray diffraction | A, B | PO4, MUK | 3 (best 0.37) |
| 6T82 | 3C-like protease from southampton virus complexed with FMOPL000542A. | x-ray diffraction | A, B | PO4, MUK | — |
| 6T8R | 3C-like protease from southampton virus complexed with FMOPL000605A. | x-ray diffraction | A, B | GVY, PO4 | — |
| 6T8T | 3C-like protease from southampton virus complexed with FMOPL000603A. | x-ray diffraction | A, B | PO4, YI6 | — |
| 6TAL | 3C-like protease from southampton virus complexed with FMOPL000227A. | x-ray diffraction | A, B | PO4, MZW | — |
| 6TAW | 3C-like protease from Southampton virus complexed with FMOPL000411a. | x-ray diffraction | A, B | N08, PO4 | 4 (best 0.45) |
| 6TAW | 3C-like protease from southampton virus complexed with FMOPL000411A. | x-ray diffraction | A, B | N08, PO4 | — |
| 6TBO | 3C-like protease from southampton virus complexed with FMOPL000363A. | x-ray diffraction | A, B | N0E, PO4 | — |
| 6TBP | 3C-like protease from southampton virus complexed with FMOPL000490A. | x-ray diffraction | A, B | N0H | — |
| 6TC1 | 3C-like protease from Southampton virus complexed with FMOPL000283a. | x-ray diffraction | A, B | MZW | 5 (best 0.39) |
| 6TC1 | 3C-like protease from southampton virus complexed with FMOPL000283A. | x-ray diffraction | A, B | MZW | — |
| 6TCF | 3C-like protease from Southampton virus complexed with XST00000642b. | x-ray diffraction | A, B | PO4, N1E | — |
| 6TCF | 3C-like protease from southampton virus complexed with XST00000642B. | x-ray diffraction | A, B | PO4, N1E | — |
| 6TGL | 3c-like protease from Southampton virus complexed with FMOPL000644a. | x-ray diffraction | A, B | PO4, LVP | 3 (best 0.38) |
| 6TGL | 3C-like protease from southampton virus complexed with FMOPL000644A. | x-ray diffraction | A, B | PO4, LVP | — |
Ligands
- PO4 · Phosphate ion · in 19 records
- MZW · 5-ethyl-1,3,4-thiadiazol-2-amine · in 3 records
- HWH · ~{N}-[2-(5-fluoranyl-1~{H}-indol-3-yl)ethyl]ethanamide · in 2 records
- JFJ · 1-(3-chlorophenyl)-N-methylmethanamine · in 2 records
- LVP · ~{N}'-(2-fluorophenyl)-1,2-oxazole-5-carbohydrazide · in 2 records
- MUK · 4,6-dimethyl-~{N}-phenyl-pyrimidin-2-amine · in 2 records
- N08 · ~{N}-[2-(4-fluorophenyl)ethyl]furan-2-carboxamide · in 2 records
- N1E · methyl quinoline-6-carboxylate · in 2 records
- GVY · 4-(5-amino-1,3,4-thiadiazol-2-yl)phenol · in 1 record
- JFM · N-(2-phenylethyl)methanesulfonamide · in 1 record
- JL7 · 2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-4-carboxylic acid · in 1 record
- JOV · 3-chloro-N-(1-hydroxy-2-methylpropan-2-yl)benzamide · in 1 record
- K2P · 2-(trifluoromethoxy)benzoic acid · in 1 record
- MH5 · 3-[(5-methylthiophen-2-yl)methylamino]benzoic acid · in 1 record
- MJW · 2-phenylmethoxyaniline · in 1 record
- MKN · 3-(5-thiophen-2-ylthiophen-2-yl)-1~{H}-pyrazole · in 1 record
- MQB · 2-(1-benzofuran-3-yl)ethanoic acid · in 1 record
- N0E · ~{N}-(4-hydroxyphenyl)-3-phenyl-propanamide · in 1 record
- N0H · ~{N}-(2-hydroxyphenyl)-2-phenoxy-ethanamide · in 1 record
- YI6 · 2-(4-ethoxyphenyl)ethanoic acid · in 1 record
Elsewhere
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