MolNFT v1 · #164281 · protein

Cryo-EM structure of alpha-synuclein fibril polymorph 2A

6SSX: “Cryo-EM structure of alpha-synuclein fibril polymorph 2A”. Electron microscopy, 6 pockets (best druggability 0.39). MolNFT v1 #164281 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6SSX
Type: protein
Length: 730 residues
Chains: 10
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Alpha-synuclein
UniProt: P37840
Pockets: 6 · best druggability 0.39

Structure

electron microscopy · 1 distinct chain · 0% helix, 71% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F, G, H, I, J	Alpha-synuclein	protein	73	0% helix, 71% strand	P37840

Pockets

6 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	94	0.39	0.77	25	empty
2	91	0.37	0.76	21	empty
3	93	0.32	0.73	19	empty
4	64	0.29	0.74	17	empty
5	63	0.29	0.74	14	empty

Interfaces

21 interfaces between chains.

A–B · 2756 Å² buried · 103 hydrogen bonds · protein-protein
F–G · 2750 Å² buried · 103 hydrogen bonds · protein-protein
I–J · 2735 Å² buried · 101 hydrogen bonds · protein-protein
D–E · 2734 Å² buried · 99 hydrogen bonds · protein-protein
B–C · 2731 Å² buried · 99 hydrogen bonds · protein-protein

Compared structures

6SSX · cryo-em structure of alpha-synuclein fibril polymorph 2A · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P37840
Elsewhere: RCSB PDB 6SSX · PDBe 6SSX · UniProt P37840

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