MolNFT v1 · #164212 · protein + RNA
Structure of the U1A variant A1-98 Y31H/Q36R/F56W triple mutant co- crystallized with RNA
6SQN · U1 small nuclear ribonucleoprotein a: “Structure of the U1A variant A1-98 Y31H/Q36R/F56W triple mutant co- crystallized with RNA”. X-ray diffraction, 6 pockets (best druggability 0.44). MolNFT v1 #164212 on GenesisL1: 3D structure…
- PDB
- 6SQN
- Type
- protein + RNA
- Length
- 334 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- U1 small nuclear ribonucleoprotein a; RNA hairpin
- UniProt
- P09012
- Pockets
- 6 · best druggability 0.44
Structure
x-ray diffraction · 4 distinct chains · 34% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | U1 small nuclear ribonucleoprotein a | protein | 96 | 31% helix, 24% strand | P09012 |
| C | U1 small nuclear ribonucleoprotein a | protein | 95 | 36% helix, 24% strand | P09012 |
| X, Y | RNA hairpin | rna | 16 | — | — |
| Z | RNA hairpin | rna | 15 | — | — |
Pockets
6 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 133 | 0.44 | 0.76 | 19 | empty |
| 2 | 141 | 0.43 | 0.76 | 21 | empty |
| 3 | 176 | 0.41 | 0.73 | 18 | empty |
| 4 | 95 | 0.40 | 0.77 | 18 | empty |
| 5 | 173 | 0.39 | 0.72 | 16 | empty |
Interfaces
8 interfaces between chains.
- A–X · 864 Ų buried · 32 hydrogen bonds · protein-nucleic
- B–Y · 851 Ų buried · 29 hydrogen bonds · protein-nucleic
- C–Z · 770 Ų buried · 31 hydrogen bonds · protein-nucleic
- A–C · 655 Ų buried · 8 hydrogen bonds · protein-protein
- A–B · 563 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 6SQN · Structure of the U1A variant A1-98 Y31H/Q36R/F56W triple mutant co-crystallized with RNA · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P09012
- Elsewhere: RCSB PDB 6SQN · PDBe 6SQN · UniProt P09012
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.