MolNFT v1 · #164108 · protein + RNA

Solution structure of the FUS/TLS RNA recognition motif in complex with U1 snrna stem loop III

6SNJ · RNA-binding protein fus: “Solution structure of the FUS/TLS RNA recognition motif in complex with U1 snrna stem loop III”. Solution nmr, 2 pockets (best druggability 0.69). MolNFT v1 #164108 on GenesisL1: 3D structure, binding sites…

PDB: 6SNJ
Type: protein + RNA
Length: 159 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RNA-binding protein fus; U1 snrna stem loop III, RNA (28-mer)
UniProt: P35637
Pockets: 2 · best druggability 0.69

Structure

solution nmr · 2 distinct chains · 22% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RNA-binding protein fus	protein	131	22% helix, 21% strand	P35637
B	U1 snrna stem loop III, RNA (28-mer)	rna	28	—	—

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	473	0.69	0.80	28	empty
2	116	0.35	0.73	22	empty

Interfaces

1 interface between chains.

A–B · 1425 Å² buried · 48 hydrogen bonds · protein-nucleic

Compared structures

6SNJ · Solution structure of the FUS/TLS RNA recognition motif in complex with U1 snRNA stem… · the same entry in another collection · chain A against A, TM-score 1.00
P35637 · AlphaFold monomer V2.0 prediction for RNA-binding protein fus (P35637) · a predicted model of the same protein · chain A against A, TM-score 0.72

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P35637
Elsewhere: RCSB PDB 6SNJ · PDBe 6SNJ · UniProt P35637

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.