MolNFT v1 · #164041 · protein
Human ERK2 with ERK1/2 inhibitor, AZD0364.
6SLG: “Human ERK2 with ERK1/2 inhibitor, AZD0364.”. X-ray diffraction, 2 ligands (LHZ, SO4). MolNFT v1 #164041 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6SLG
- Type
- protein
- Length
- 337 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P28482
- Ligands
- LHZ, SO4
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 332 | — | P28482 |
| B | — | protein | 5 | — | — |
Ligands and binding sites
- LHZ · (6~{R})-7-[[3,4-bis(fluoranyl)phenyl]methyl]-6-(methoxymethyl)-2-[5-methyl-2-[(2-methylpyrazol-3-yl) amino]pyrimidin-4-yl]-5,6-dihydroimidazo[1,2-a]pyrazin-8-one · ligand · chains A
- SO4 · Sulfate ion · ion · 2 copies · chains A
- EDO · 1,2-ethanediol · additive · 4 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6SLG · Human ERK2 with ERK1/2 inhibitor, AZD0364. · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P28482
- Elsewhere: RCSB PDB 6SLG · PDBe 6SLG · UniProt P28482
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