MolNFT v1 · #164031 · protein

Alpha-actinin from entamoeba histolytica

6SL2 · Calponin homology domain protein putative: “Alpha-actinin from entamoeba histolytica”. X-ray diffraction, 2 ligands (CA, MG), 4 pockets (best druggability 0.50). MolNFT v1 #164031 on GenesisL1: 3D structure, binding sites and…

PDB: 6SL2
Type: protein
Length: 619 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Calponin homology domain protein putative
UniProt: C4LWU6
Ligands: CA, MG
Pockets: 4 · best druggability 0.50

Structure

x-ray diffraction · 1 distinct chain · 69% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Calponin homology domain protein putative	protein	619	69% helix, 1% strand	C4LWU6

Ligands and binding sites

CA · Calcium ion · metal · chains A
MG · Magnesium ion · metal · chains A
TRS · 2-amino-2-hydroxymethyl-propane-1,3-diol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	251	0.50	0.75	34	empty
2	82	0.37	0.76	11	empty
3	51	0.35	0.79	13	empty
4	59	0.33	0.76	14	empty

Modifications

Observed in the structure: 13 modified (methylation).

Compared structures

6SL2 · Alpha-actinin from entamoeba histolytica · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt C4LWU6
Elsewhere: RCSB PDB 6SL2 · PDBe 6SL2 · UniProt C4LWU6

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