MolNFT v1 · #163940 · protein

Crystal structure of the C-lobe of drosophila arc 2

6SIE · Activity-regulated cytoskeleton associated protein 2: “Crystal structure of the C-lobe of drosophila arc 2”. X-ray diffraction, 1 ligand (SO4), 2 pockets (best druggability 0.35). MolNFT v1 #163940 on GenesisL1: 3D structure…

PDB: 6SIE
Type: protein
Length: 333 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Activity-regulated cytoskeleton associated protein 2
UniProt: Q7JV70
Ligands: SO4
Pockets: 2 · best druggability 0.35

Structure

x-ray diffraction · 4 distinct chains · 65% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Activity-regulated cytoskeleton associated protein 2	protein	84	65% helix, 0% strand	Q7JV70
B	Activity-regulated cytoskeleton associated protein 2	protein	85	64% helix, 0% strand	Q7JV70
C	Activity-regulated cytoskeleton associated protein 2	protein	83	63% helix, 0% strand	Q7JV70
D	Activity-regulated cytoskeleton associated protein 2	protein	81	67% helix, 0% strand	Q7JV70

Ligands and binding sites

SO4 · Sulfate ion · ion · 6 copies · chains A, B, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	75	0.35	0.76	20	empty
2	60	0.27	0.73	16	empty

Interfaces

4 interfaces between chains.

C–D · 765 Å² buried · 6 hydrogen bonds · protein-protein
A–B · 749 Å² buried · 7 hydrogen bonds · protein-protein
A–D · 326 Å² buried · 5 hydrogen bonds · protein-protein
A–C · 150 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

6SIE · Crystal structure of the C-lobe of drosophila Arc 2 · the same entry in another collection · chain D against D, TM-score 1.00
Q7JV70 · AlphaFold monomer V2.0 prediction for activity-regulated cytoskeleton associated protein… · a predicted model of the same protein · chain C against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q7JV70
Elsewhere: RCSB PDB 6SIE · PDBe 6SIE · UniProt Q7JV70

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