Research workbench
Crystal structure of the C-lobe of drosophila arc 2
Analyse Crystal structure of the C-lobe of drosophila arc 2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6SIE
- Type
- protein
- Length
- 333 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Activity-regulated cytoskeleton associated protein 2
- UniProt
- Q7JV70
- Ligands
- SO4
- Pockets
- 2 · best druggability 0.35
Structure
x-ray diffraction · 4 distinct chains · 65% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Activity-regulated cytoskeleton associated protein 2 | protein | 84 | 65% helix, 0% strand | Q7JV70 |
| B | Activity-regulated cytoskeleton associated protein 2 | protein | 85 | 64% helix, 0% strand | Q7JV70 |
| C | Activity-regulated cytoskeleton associated protein 2 | protein | 83 | 63% helix, 0% strand | Q7JV70 |
| D | Activity-regulated cytoskeleton associated protein 2 | protein | 81 | 67% helix, 0% strand | Q7JV70 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 6 copies · chains A, B, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 75 | 0.35 | 0.76 | 20 | empty |
| 2 | 60 | 0.27 | 0.73 | 16 | empty |
Interfaces
4 interfaces between chains.
- C–D · 765 Ų buried · 6 hydrogen bonds · protein-protein
- A–B · 749 Ų buried · 7 hydrogen bonds · protein-protein
- A–D · 326 Ų buried · 5 hydrogen bonds · protein-protein
- A–C · 150 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 6SIE · Crystal structure of the C-lobe of drosophila Arc 2 · the same entry in another collection · chain D against D, TM-score 1.00
- Q7JV70 · AlphaFold monomer V2.0 prediction for activity-regulated cytoskeleton associated protein… · a predicted model of the same protein · chain C against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7JV70
- Elsewhere: RCSB PDB 6SIE · PDBe 6SIE · UniProt Q7JV70
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.