MolNFT v1 · #163926 · protein

P53 cancer mutant Y220C

6SHZ · Cellular tumor antigen P53: “P53 cancer mutant Y220C”. X-ray diffraction, 1 ligand (ZN), 3 pockets (best druggability 0.64). MolNFT v1 #163926 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6SHZ
Type: protein
Length: 395 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cellular tumor antigen P53
UniProt: P04637
Ligands: ZN
Pockets: 3 · best druggability 0.64

Structure

x-ray diffraction · 2 distinct chains · 9% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cellular tumor antigen P53	protein	197	10% helix, 33% strand	P04637
B	Cellular tumor antigen P53	protein	198	8% helix, 33% strand	P04637

Ligands and binding sites

ZN · Zinc ion · metal · 2 copies · chains A, B
EDO · 1,2-ethanediol · additive · 2 copies · chains A
GOL · Glycerol · additive · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	442	0.64	0.77	50	EDO
2	127	0.41	0.75	20	empty
3	90	0.36	0.75	19	empty

Interfaces

1 interface between chains.

A–B · 304 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

6SHZ · p53 cancer mutant Y220C · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P04637
Elsewhere: RCSB PDB 6SHZ · PDBe 6SHZ · UniProt P04637

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