TEAD4 bound to a FAM181B peptide

Structure

x-ray diffraction · 2 distinct chains · 20% helix, 49% strand (DSSP).

Ligands and binding sites

• ACE · Acetyl group · ligand · chains L
• NH2 · Amino group · ion · chains L

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–L · 762 Ų buried · 14 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 covalent, 1 modified (covalent ligand, nonstandard).

Compared structures

• 6SEO · TEAD4 bound to a FAM181B peptide · the same entry in another collection · chain A against A, TM-score 1.00
• Q15561 · AlphaFold monomer V2.0 prediction for transcriptional enhancer factor tef-3 (Q15561) · a predicted model of the same protein · chain A against A, TM-score 0.98
• A6NEQ2 · AlphaFold monomer V2.0 prediction for protein FAM181B (A6NEQ2) · a predicted model of the same protein · chain L against A, TM-score 0.54

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q15561
• Every structure of UniProt A6NEQ2
• Elsewhere: RCSB PDB 6SEO · PDBe 6SEO · UniProt Q15561 · UniProt A6NEQ2