MolNFT v1 · #163809 · protein + RNA

Solution structure of STAUFEN1 DSRBD3+4 - HARF1 sbs dsrna complex.

6SDW · Double-stranded RNA-binding protein staufen homolog 1: “Solution structure of STAUFEN1 DSRBD3+4 - HARF1 sbs dsrna complex.”. Solution nmr, 2 pockets (best druggability 0.72). MolNFT v1 #163809 on GenesisL1: 3D structure, binding…

PDB: 6SDW
Type: protein + RNA
Length: 211 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Double-stranded RNA-binding protein staufen homolog 1; HARF1 sbs dsrna
UniProt: O95793
Pockets: 2 · best druggability 0.72

Structure

solution nmr · 2 distinct chains · 25% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Double-stranded RNA-binding protein staufen homolog 1	protein	177	25% helix, 15% strand	O95793
B	HARF1 sbs dsrna	rna	34	—	—

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	559	0.72	0.81	44	empty
2	191	0.50	0.77	22	empty

Interfaces

1 interface between chains.

A–B · 2397 Å² buried · 65 hydrogen bonds · protein-nucleic

Compared structures

6SDW · Solution structure of Staufen1 dsRBD3+4 - hARF1 SBS dsRNA complex. · the same entry in another collection · chain A against A, TM-score 1.00
O95793 · AlphaFold monomer V2.0 prediction for double-stranded RNA-binding protein staufen homolog… · a predicted model of the same protein · chain A against A, TM-score 0.51

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O95793
Elsewhere: RCSB PDB 6SDW · PDBe 6SDW · UniProt O95793

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