Structure of GLUK1 ligand-binding domain (S1S2) in complex with N-(7- (1H-imidazol-1-yl)-2,3-dioxo-6-(trifluoromethyl)-3,4- dihydroquinoxalin-1(2H)-yl benzamide at 2.3 a resolution

Structure

x-ray diffraction · 1 distinct chain · 39% helix, 26% strand (DSSP).

Ligands and binding sites

• L5H · ~{N}-[7-imidazol-1-yl-2,3-bis(oxidanylidene)-6-(trifluoromethyl)-4~{H}-quinoxalin-1-yl]benzamide · ligand · chains A
• SO4 · Sulfate ion · ion · 2 copies · chains A
• CL · Chloride ion · ion · 2 copies · chains A
• GOL · Glycerol · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Compared structures

• 6SBT · Structure of GluK1 ligand-binding domain (S1S2) in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
• P22756 · AlphaFold monomer V2.0 prediction for glutamate receptor ionotropic, kainate 1 (P22756) · a predicted model of the same protein · chain A against A, TM-score 0.86

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P22756
• Elsewhere: RCSB PDB 6SBT · PDBe 6SBT · UniProt P22756