MolNFT v1 · #163728 · protein
X-ray structure of mus musculus fumarylacetoacetate hydrolase domain containing protein 1 (FAHD1) apo-form uuncomplexed
6SBJ · Acylpyruvase FAHD1, mitochondrial: “X-ray structure of mus musculus fumarylacetoacetate hydrolase domain containing protein 1 (FAHD1) apo-form…”. X-ray diffraction, 2 ligands (MG, CL), 14 pockets (best druggability 0.57). MolNFT v1…
- PDB
- 6SBJ
- Type
- protein
- Length
- 832 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Acylpyruvase FAHD1, mitochondrial
- EC
- 3.7.1.5, 4.1.1.112
- UniProt
- Q8R0F8
- Ligands
- MG, CL
- Pockets
- 14 · best druggability 0.57
Structure
x-ray diffraction · 4 distinct chains · 22% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Acylpyruvase FAHD1, mitochondrial (EC 3.7.1.5, 4.1.1.112) | protein | 211 | 21% helix, 36% strand | Q8R0F8 |
| B | Acylpyruvase FAHD1, mitochondrial (EC 3.7.1.5, 4.1.1.112) | protein | 212 | 21% helix, 35% strand | Q8R0F8 |
| C | Acylpyruvase FAHD1, mitochondrial (EC 3.7.1.5, 4.1.1.112) | protein | 204 | 22% helix, 37% strand | Q8R0F8 |
| D | Acylpyruvase FAHD1, mitochondrial (EC 3.7.1.5, 4.1.1.112) | protein | 205 | 22% helix, 38% strand | Q8R0F8 |
Ligands and binding sites
- MG · Magnesium ion · metal · 6 copies · chains A, B, C, D
- CL · Chloride ion · ion · 6 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
14 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 239 | 0.57 | 0.78 | 32 | empty |
| 2 | 430 | 0.57 | 0.74 | 45 | empty |
| 3 | 169 | 0.50 | 0.77 | 30 | empty |
| 4 | 161 | 0.47 | 0.76 | 26 | empty |
| 5 | 129 | 0.46 | 0.78 | 26 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1358 Ų buried · 20 hydrogen bonds · protein-protein
- C–D · 1320 Ų buried · 23 hydrogen bonds · protein-protein
- A–D · 176 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 6SBJ · X-ray structure of mus musculus Fumarylacetoacetate hydrolase domain containing protein 1… · the same entry in another collection · chain D against D, TM-score 1.00
- Q8R0F8 · AlphaFold monomer V2.0 prediction for acylpyruvase FAHD1, mitochondrial (Q8R0F8) · a predicted model of the same protein · chain C against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8R0F8
- Elsewhere: RCSB PDB 6SBJ · PDBe 6SBJ · UniProt Q8R0F8
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