Structural and functional characterisation of three novel fungal amylases with enhanced stability and pH tolerance

Structure

x-ray diffraction · 1 distinct chain · 35% helix, 19% strand (DSSP).

Ligands and binding sites

• AC1 · 4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranose · ligand · 2 copies · chains A
• GLC · alpha-D-glucopyranose · sugar · 2 copies · chains A
• BGC · beta-D-glucopyranose · sugar · chains A
• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · chains A
• CA · Calcium ion · metal · chains A
• SO4 · Sulfate ion · ion · 6 copies · chains A
• EDO · 1,2-ethanediol · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Modifications

Observed in the structure: 2 disulfide, 1 glycan (disulfide, N-glycosylation).

Compared structures

• 6SAO · Structural and functional characterisation of three novel fungal amylases with enhanced… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Elsewhere: RCSB PDB 6SAO · PDBe 6SAO