MolNFT v1 · #163538 · protein
Apoferritin from mouse at 1.84 ångström resolution
6S61 · Ferritin heavy chain: “Apoferritin from mouse at 1.84 ångström resolution”. Electron microscopy, 2 ligands (ZN, FE), 20 pockets (best druggability 0.69). MolNFT v1 #163538 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 6S61
- Type
- protein
- Length
- 4,128 residues
- Chains
- 24
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ferritin heavy chain
- EC
- 1.16.3.1
- UniProt
- P09528
- Ligands
- ZN, FE
- Pockets
- 20 · best druggability 0.69
Structure
electron microscopy · 1 distinct chain · 73% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X | Ferritin heavy chain (EC 1.16.3.1) | protein | 172 | 73% helix, 1% strand | P09528 |
Ligands and binding sites
- ZN · Zinc ion · metal · 24 copies · chains A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X
- FE · Fe (III) ion · metal · 6 copies · chains A, E, V, W, B, H, O, P, C, G, K, T, D, F, L, R, I, J, M, N, Q, S, U, X
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 304 | 0.69 | 0.83 | 40 | empty |
| 2 | 300 | 0.68 | 0.83 | 41 | empty |
| 3 | 287 | 0.68 | 0.83 | 38 | empty |
| 4 | 295 | 0.68 | 0.83 | 39 | empty |
| 5 | 300 | 0.67 | 0.82 | 40 | empty |
Interfaces
72 interfaces between chains.
- E–U · 1531 Ų buried · 36 hydrogen bonds · protein-protein
- J–W · 1531 Ų buried · 36 hydrogen bonds · protein-protein
- C–I · 1529 Ų buried · 36 hydrogen bonds · protein-protein
- G–X · 1529 Ų buried · 36 hydrogen bonds · protein-protein
- A–L · 1529 Ų buried · 36 hydrogen bonds · protein-protein
Compared structures
- 6S61 · Apoferritin from mouse at 1.84 angstrom resolution · the same entry in another collection · chain G against G, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P09528
- Elsewhere: RCSB PDB 6S61 · PDBe 6S61 · UniProt P09528
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