Crystal structure of cysteinyl leukotriene receptor 1 in complex with pranlukast

Structure

x-ray diffraction · 1 distinct chain · 81% helix, 1% strand (DSSP).

Ligands and binding sites

• KNT · pranlukast · ligand · chains A
• OLA · Oleic acid · ligand · chains A
• NA · Sodium ion · metal · chains A
• OLC · (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate · additive · 9 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

• 6RZ4 · Crystal structure of cysteinyl leukotriene receptor 1 in complex with pranlukast · the same entry in another collection · chain A against A, TM-score 1.00
• Q9Y271 · AlphaFold monomer V2.0 prediction for cysteinyl leukotriene receptor 1 (Q9Y271) · a predicted model of the same protein · chain A against A, TM-score 0.72
• P0ABE7 · AlphaFold monomer V2.0 prediction for soluble cytochrome B562 (P0ABE7) · a predicted model of the same protein · chain A against A, TM-score 0.29

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q9Y271
• Every structure of UniProt P0ABE7
• Elsewhere: RCSB PDB 6RZ4 · PDBe 6RZ4 · UniProt Q9Y271 · UniProt P0ABE7