MolNFT v1 · #163305 · protein
Crystal structure of a complex between the DNA-binding domain of P53 and the carboxyl-terminal conserved region of iaspp
6RZ3 · Cellular tumor antigen P53: “Crystal structure of a complex between the DNA-binding domain of P53 and the carboxyl-terminal conserved…”. X-ray diffraction, 1 ligand (ZN), 3 pockets (best druggability 0.55). MolNFT v1 #163305 on…
- PDB
- 6RZ3
- Type
- protein
- Length
- 368 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cellular tumor antigen P53; Rela-associated inhibitor
- UniProt
- P04637, Q8WUF5
- Ligands
- ZN
- Pockets
- 3 · best druggability 0.55
Structure
x-ray diffraction · 2 distinct chains · 20% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cellular tumor antigen P53 | protein | 201 | 10% helix, 34% strand | P04637 |
| B | Rela-associated inhibitor | protein | 167 | 32% helix, 16% strand | Q8WUF5 |
Ligands and binding sites
- ZN · Zinc ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 281 | 0.55 | 0.76 | 29 | empty |
| 2 | 100 | 0.39 | 0.76 | 19 | empty |
| 3 | 65 | 0.31 | 0.75 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 662 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 6RZ3 · Crystal structure of a complex between the DNA-binding domain of p53 and the… · the same entry in another collection · chain A against A, TM-score 1.00
- Q8WUF5 · AlphaFold monomer V2.0 prediction for rela-associated inhibitor (Q8WUF5) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04637
- Every structure of UniProt Q8WUF5
- Elsewhere: RCSB PDB 6RZ3 · PDBe 6RZ3 · UniProt P04637 · UniProt Q8WUF5
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.