MolNFT v1 · #163179 · protein

Human ALANINE:GLYOXYLATE aminotransferase major allele (agt-ma); with pmp in the active site

6RV0 · Serine--pyruvate aminotransferase: “Human ALANINE:GLYOXYLATE aminotransferase major allele (agt-ma); with pmp in the active site”. X-ray diffraction, 1 ligand (PMP), 1 pocket (best druggability 0.51). MolNFT v1 #163179 on GenesisL1…

PDB: 6RV0
Type: protein
Length: 384 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Serine--pyruvate aminotransferase
EC: 2.6.1.51, 2.6.1.44
UniProt: P21549
Ligands: PMP
Pockets: 1 · best druggability 0.51

Structure

x-ray diffraction · 1 distinct chain · 42% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Serine--pyruvate aminotransferase (EC 2.6.1.51, 2.6.1.44)	protein	384	42% helix, 14% strand	P21549

Ligands and binding sites

PMP · 4'-deoxy-4'-aminopyridoxal-5'-phosphate · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	109	0.51	0.81	21	PMP

Compared structures

6RV0 · human Alanine:Glyoxylate Aminotransferase major allele (AGT-Ma); with PMP in the active… · the same entry in another collection · chain A against A, TM-score 1.00
P21549 · AlphaFold monomer V2.0 prediction for serine--pyruvate aminotransferase (P21549) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P21549
Elsewhere: RCSB PDB 6RV0 · PDBe 6RV0 · UniProt P21549

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