MolNFT v1 · #16296 · protein
Crystal structure analysis of the FGF10-FGFR2B complex
1NUN · Fibroblast growth factor-10: “Crystal structure analysis of the FGF10-FGFR2B complex”. X-ray diffraction, 1 ligand (SO4), 2 pockets (best druggability 0.53). MolNFT v1 #16296 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 1NUN
- Type
- protein
- Length
- 348 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fibroblast growth factor-10; Fibroblast growth factor receptor 2 isoform 2
- UniProt
- O15520, P21802
- Ligands
- SO4
- Pockets
- 2 · best druggability 0.53
Structure
x-ray diffraction · 2 distinct chains · 7% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fibroblast growth factor-10 | protein | 139 | 7% helix, 48% strand | O15520 |
| B | Fibroblast growth factor receptor 2 isoform 2 | protein | 209 | 6% helix, 49% strand | P21802 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 2 copies · chains A
- 15P · Polyethylene glycol (N=34) · additive · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 185 | 0.53 | 0.78 | 33 | empty |
| 2 | 183 | 0.49 | 0.76 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 1454 Ų buried · 25 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 modified, 1 disulfide (engineered, disulfide).
Compared structures
- 1NUN · Crystal Structure Analysis of the FGF10-FGFR2b Complex · the same entry in another collection · chain A against A, TM-score 1.00
- O15520 · AlphaFold monomer V2.0 prediction for fibroblast growth factor 10 (O15520) · a predicted model of the same protein · chain A against A, TM-score 0.97
- P21802 · AlphaFold monomer V2.0 prediction for fibroblast growth factor receptor 2 (P21802) · a predicted model of the same protein · chain B against A, TM-score 0.63
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O15520
- Every structure of UniProt P21802
- Elsewhere: RCSB PDB 1NUN · PDBe 1NUN · UniProt O15520 · UniProt P21802
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