MolNFT v1 · #162937 · protein
Crystal structure of the dimerization domain of GEMIN5 at 2.7 a
6RNS · Gem-associated protein 5: “Crystal structure of the dimerization domain of GEMIN5 at 2.7 a”. X-ray diffraction, 1 ligand (IOD), 5 pockets (best druggability 0.43). MolNFT v1 #162937 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6RNS
- Type
- protein
- Length
- 487 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gem-associated protein 5
- UniProt
- Q8TEQ6
- Ligands
- IOD
- Pockets
- 5 · best druggability 0.43
Structure
x-ray diffraction · 2 distinct chains · 77% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Gem-associated protein 5 | protein | 243 | 77% helix, 0% strand | Q8TEQ6 |
| B | Gem-associated protein 5 | protein | 244 | 77% helix, 0% strand | Q8TEQ6 |
Ligands and binding sites
- IOD · Iodide ion · ion · 13 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 113 | 0.43 | 0.77 | 20 | empty |
| 2 | 108 | 0.39 | 0.75 | 23 | empty |
| 3 | 58 | 0.31 | 0.76 | 18 | empty |
| 4 | 60 | 0.29 | 0.73 | 12 | empty |
| 5 | 53 | 0.28 | 0.75 | 16 | IOD |
Interfaces
1 interface between chains.
- A–B · 3474 Ų buried · 34 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8TEQ6
- Elsewhere: RCSB PDB 6RNS · PDBe 6RNS · UniProt Q8TEQ6
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