MolNFT v1 · #162861 · protein
Structure of the mechanosensitive channel mscs embedded in the membrane bilayer
6RLD · Small-conductance mechanosensitive channel: “Structure of the mechanosensitive channel mscs embedded in the membrane bilayer”. Electron microscopy, 1 ligand (PCW), 20 pockets (best druggability 0.75). MolNFT v1 #162861 on GenesisL1…
- PDB
- 6RLD
- Type
- protein
- Length
- 1,855 residues
- Chains
- 7
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Small-conductance mechanosensitive channel
- UniProt
- P0C0S1
- Ligands
- PCW
- Pockets
- 20 · best druggability 0.75
Structure
electron microscopy · 1 distinct chain · 49% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G | Small-conductance mechanosensitive channel | protein | 265 | 49% helix, 23% strand | P0C0S1 |
Ligands and binding sites
- PCW · 1,2-dioleoyl-sn-glycero-3-phosphocholine · ligand · 21 copies · chains A, F, G, B, C, D, E
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 17 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 312 | 0.75 | 0.85 | 21 | empty |
| 2 | 1084 | 0.71 | 0.75 | 50 | empty |
| 3 | 96 | 0.63 | 0.89 | 18 | empty |
| 4 | 123 | 0.62 | 0.86 | 23 | empty |
| 5 | 109 | 0.62 | 0.87 | 20 | empty |
Interfaces
14 interfaces between chains.
- A–G · 2841 Ų buried · 24 hydrogen bonds · protein-protein
- C–D · 2821 Ų buried · 24 hydrogen bonds · protein-protein
- D–E · 2817 Ų buried · 24 hydrogen bonds · protein-protein
- E–F · 2811 Ų buried · 24 hydrogen bonds · protein-protein
- F–G · 2810 Ų buried · 22 hydrogen bonds · protein-protein
Compared structures
- 6RLD · Structure of the mechanosensitive channel mscs embedded in the membrane bilayer · the same entry in another collection · chain G against G, TM-score 1.00
- P0C0S1 · AlphaFold monomer V2.0 prediction for small-conductance mechanosensitive channel (P0C0S1) · a predicted model of the same protein · chain A against A, TM-score 0.81
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0C0S1
- Elsewhere: RCSB PDB 6RLD · PDBe 6RLD · UniProt P0C0S1
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