MolNFT v1 · #162745 · protein

Structure of pore-forming amyloid-beta tetramers

6RHY · Amyloid beta A4 protein: “Structure of pore-forming amyloid-beta tetramers”. Solution nmr. MolNFT v1 #162745 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6RHY
Type: protein
Length: 168 residues
Chains: 4
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Amyloid beta A4 protein
UniProt: P05067

Structure

solution nmr · 1 distinct chain · 0% helix, 71% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Amyloid beta A4 protein	protein	42	0% helix, 71% strand	P05067

Interfaces

5 interfaces between chains.

B–D · 627 Å² buried · 21 hydrogen bonds · protein-protein
C–D · 543 Å² buried · 20 hydrogen bonds · protein-protein
A–B · 538 Å² buried · 20 hydrogen bonds · protein-protein
A–D · 126 Å² buried · 0 hydrogen bonds · protein-protein
B–C · 124 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

6RHY · Structure of pore-forming amyloid-beta tetramers · the same entry in another collection · chain D against D, TM-score 1.00
P05067 · AlphaFold monomer V2.0 prediction for amyloid-beta precursor protein (P05067) · a predicted model of the same protein · chain A against A, TM-score 0.38

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P05067
Elsewhere: RCSB PDB 6RHY · PDBe 6RHY · UniProt P05067

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