MolNFT v1 · #162663 · protein
ERK2 MAP kinase with the activation loop of P38ALPHA
6RFO · Mitogen-activated protein kinase 1,MITOGEN-activated…: “ERK2 MAP kinase with the activation loop of P38ALPHA”. X-ray diffraction, 4 pockets (best druggability 0.50). MolNFT v1 #162663 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6RFO
- Type
- protein
- Length
- 316 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitogen-activated protein kinase 1,MITOGEN-activated protein kinase 14,MITOGEN-activated…
- EC
- 2.7.11.24
- UniProt
- P63086, Q16539
- Pockets
- 4 · best druggability 0.50
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mitogen-activated protein kinase 1,MITOGEN-activated protein kinase 14,MITOGEN-activated protein kinase 1 (EC 2.7.11.24) | protein | 316 | 43% helix, 13% strand | P63086, Q16539 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 223 | 0.50 | 0.75 | 37 | empty |
| 2 | 64 | 0.48 | 0.84 | 14 | empty |
| 3 | 94 | 0.41 | 0.77 | 16 | empty |
| 4 | 51 | 0.29 | 0.75 | 13 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63086
- Every structure of UniProt Q16539
- Elsewhere: RCSB PDB 6RFO · PDBe 6RFO · UniProt P63086 · UniProt Q16539
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.