MolNFT v1 · #162459 · protein

Cryo-EM structure of autoinhibited human talin-1

6R9T: “Cryo-EM structure of autoinhibited human talin-1”. Electron microscopy, 20 pockets (best druggability 0.82). MolNFT v1 #162459 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6R9T
Type: protein
Length: 2,185 residues
Chains: 1
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Talin-1
UniProt: Q9Y490
Pockets: 20 · best druggability 0.82

Structure

electron microscopy · 1 distinct chain · 75% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Talin-1	protein	2185	75% helix, 2% strand	Q9Y490

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	307	0.82	0.92	67	empty
2	711	0.82	0.86	90	empty
3	416	0.79	0.88	76	empty
4	425	0.78	0.87	76	empty
5	457	0.77	0.85	77	empty

Compared structures

6R9T · Cryo-EM structure of autoinhibited human talin-1 · the same entry in another collection · chain A against A, TM-score 1.00
Q9Y490 · AlphaFold monomer V2.0 prediction for talin-1 (Q9Y490) · a predicted model of the same protein · chain A against A, TM-score 0.65

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9Y490
Elsewhere: RCSB PDB 6R9T · PDBe 6R9T · UniProt Q9Y490

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