MolNFT v1 · #16234 · protein
The sulfotransferase domain of human haparin sulfate N-DEACETYLASE/N- sulfotransferase
1NST · Heparan sulfate N-DEACETYLASE/N-sulfotransferase: “The sulfotransferase domain of human haparin sulfate N-DEACETYLASE/N- sulfotransferase”. X-ray diffraction, 1 ligand (A3P), 2 pockets (best druggability 0.72). MolNFT v1 #16234 on…
- PDB
- 1NST
- Type
- protein
- Length
- 282 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Heparan sulfate N-DEACETYLASE/N-sulfotransferase
- EC
- 2.8.2.-
- UniProt
- P52848
- Ligands
- A3P
- Pockets
- 2 · best druggability 0.72
Structure
x-ray diffraction · 1 distinct chain · 46% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Heparan sulfate N-DEACETYLASE/N-sulfotransferase (EC 2.8.2.-) | protein | 282 | 46% helix, 13% strand | P52848 |
Ligands and binding sites
- A3P · Adenosine-3'-5'-diphosphate · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 499 | 0.72 | 0.81 | 52 | A3P |
| 2 | 55 | 0.31 | 0.76 | 12 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 1NST · The sulfotransferase domain of human haparin sulfate N-DEACETYLASE/N-sulfotransferase · the same entry in another collection · chain A against A, TM-score 1.00
- P52848 · AlphaFold monomer V2.0 prediction for bifunctional heparan sulfate… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P52848
- Elsewhere: RCSB PDB 1NST · PDBe 1NST · UniProt P52848
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