MolNFT v1 · #162297 · protein
Structure of a soluble domain of adenylyl cyclase bound to an activated stimulatory G protein
6R4P · Adenylate cyclase 9: “Structure of a soluble domain of adenylyl cyclase bound to an activated stimulatory G protein”. Electron microscopy, 2 ligands (GSP, MG), 12 pockets (best druggability 0.76). MolNFT v1 #162297 on GenesisL1: 3D…
- PDB
- 6R4P
- Type
- protein
- Length
- 819 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Adenylate cyclase 9; Guanine nucleotide-binding protein G(S) subunit alpha isoforms short
- UniProt
- E1BM79, P04896
- Ligands
- GSP, MG
- Pockets
- 12 · best druggability 0.76
Structure
electron microscopy · 2 distinct chains · 43% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Adenylate cyclase 9 | protein | 478 | 38% helix, 23% strand | E1BM79 |
| B | Guanine nucleotide-binding protein G(S) subunit alpha isoforms short | protein | 341 | 50% helix, 12% strand | P04896 |
Ligands and binding sites
- GSP · 5'-guanosine-diphosphate-monothiophosphate · ligand · chains B
- MG · Magnesium ion · metal · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
12 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 531 | 0.76 | 0.83 | 63 | GSP, MG |
| 2 | 869 | 0.75 | 0.79 | 76 | empty |
| 3 | 122 | 0.65 | 0.88 | 26 | empty |
| 4 | 216 | 0.64 | 0.83 | 34 | empty |
| 5 | 236 | 0.56 | 0.78 | 32 | empty |
Interfaces
1 interface between chains.
- A–B · 1061 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 6R4P · Structure of a soluble domain of adenylyl cyclase bound to an activated stimulatory G… · the same entry in another collection · chain A against A, TM-score 1.00
- P04896 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(S) subunit… · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt E1BM79
- Every structure of UniProt P04896
- Elsewhere: RCSB PDB 6R4P · PDBe 6R4P · UniProt E1BM79 · UniProt P04896
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