MolNFT v1 · #162286 · protein
Crystal structure of human gfat-1 in complex with glucose-6-phosphate and L-glu
6R4E · Glutamine--fructose-6-phosphate aminotransferase…: “Crystal structure of human gfat-1 in complex with glucose-6-phosphate and L-glu”. X-ray diffraction, 2 ligands (G6Q, GLU), 14 pockets (best druggability 0.87). MolNFT v1 #162286 on…
- PDB
- 6R4E
- Type
- protein
- Length
- 1,320 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
- EC
- 2.6.1.16
- UniProt
- Q06210
- Ligands
- G6Q, GLU
- Pockets
- 14 · best druggability 0.87
Structure
x-ray diffraction · 2 distinct chains · 38% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (EC 2.6.1.16) | protein | 663 | 38% helix, 25% strand | Q06210 |
| B | Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (EC 2.6.1.16) | protein | 657 | 38% helix, 23% strand | Q06210 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
14 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 650 | 0.87 | 0.91 | 60 | empty |
| 2 | 1114 | 0.79 | 0.81 | 98 | G6Q, GLU |
| 3 | 123 | 0.79 | 0.97 | 28 | G6Q |
| 4 | 482 | 0.73 | 0.82 | 58 | empty |
| 5 | 381 | 0.72 | 0.83 | 42 | empty |
Interfaces
1 interface between chains.
- A–B · 2907 Ų buried · 50 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (phosphorylation).
Compared structures
- 6R4E · Crystal structure of human GFAT-1 in complex with Glucose-6-Phosphate and L-Glu · the same entry in another collection · chain B against B, TM-score 1.00
- Q06210 · AlphaFold monomer V2.0 prediction for glutamine--fructose-6-phosphate aminotransferase… · a predicted model of the same protein · chain B against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q06210
- Elsewhere: RCSB PDB 6R4E · PDBe 6R4E · UniProt Q06210
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