MolNFT v1 · #162262 · protein
The structure of a membrane adenylyl cyclase bound to an activated stimulatory G protein
6R3Q · Adenylate cyclase 9: “The structure of a membrane adenylyl cyclase bound to an activated stimulatory G protein”. Electron microscopy, 2 ligands (GSP, MG), 18 pockets (best druggability 0.74). MolNFT v1 #162262 on GenesisL1: 3D…
- PDB
- 6R3Q
- Type
- protein
- Length
- 1,182 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Adenylate cyclase 9; Guanine nucleotide-binding protein G(S) subunit alpha isoforms short
- UniProt
- E1BM79, P04896
- Ligands
- GSP, MG
- Pockets
- 18 · best druggability 0.74
Structure
electron microscopy · 2 distinct chains · 54% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Adenylate cyclase 9 | protein | 841 | 57% helix, 14% strand | E1BM79 |
| B | Guanine nucleotide-binding protein G(S) subunit alpha isoforms short | protein | 341 | 47% helix, 9% strand | P04896 |
Ligands and binding sites
- GSP · 5'-guanosine-diphosphate-monothiophosphate · ligand · chains B
- MG · Magnesium ion · metal · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
18 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 881 | 0.74 | 0.78 | 75 | empty |
| 2 | 134 | 0.73 | 0.92 | 26 | empty |
| 3 | 311 | 0.72 | 0.85 | 43 | GSP, MG |
| 4 | 684 | 0.69 | 0.77 | 62 | empty |
| 5 | 174 | 0.67 | 0.86 | 29 | empty |
Interfaces
1 interface between chains.
- A–B · 1040 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 6R3Q · The structure of a membrane adenylyl cyclase bound to an activated stimulatory G protein · the same entry in another collection · chain A against A, TM-score 1.00
- P04896 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(S) subunit… · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt E1BM79
- Every structure of UniProt P04896
- Elsewhere: RCSB PDB 6R3Q · PDBe 6R3Q · UniProt E1BM79 · UniProt P04896
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