MolNFT v1 · #162179 · protein
Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with compound 11A
6R18: “Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with compound 11A”. X-ray diffraction, 5 ligands (EF2, JOQ, ZN). MolNFT v1 #162179 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6R18
- Type
- protein
- Length
- 329 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- A4TVL0
- Ligands
- EF2, JOQ, ZN, PO4, CL
Structure
x-ray diffraction · 4 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 111 | — | A4TVL0 |
| B | — | protein | 109 | — | A4TVL0 |
| C | — | protein | 106 | — | A4TVL0 |
| D | — | protein | 3 | — | — |
Ligands and binding sites
- EF2 · S-Thalidomide · ligand · 2 copies · chains A, C, D
- JOQ · [4-(aminomethyl)phenyl]methyl ~{N}-[(3~{S})-2,5-bis(oxidanylidene)pyrrolidin-3-yl]carbamate · ligand · chains B
- ZN · Zinc ion · metal · 3 copies · chains A, B, C
- PO4 · Phosphate ion · ion · 3 copies · chains A, B, C, D
- CL · Chloride ion · ion · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6R18 · Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with compound 11a · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A4TVL0
- Elsewhere: RCSB PDB 6R18 · PDBe 6R18 · UniProt A4TVL0
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