MolNFT v1 · #162008 · protein

Cryoem structure of the human clc-1 chloride channel, low pH

6QVU · Chloride channel protein 1: “Cryoem structure of the human clc-1 chloride channel, low pH”. Electron microscopy, 20 pockets (best druggability 0.84). MolNFT v1 #162008 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6QVU
Type: protein
Length: 1,198 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Chloride channel protein 1
UniProt: P35523
Pockets: 20 · best druggability 0.84

Structure

electron microscopy · 1 distinct chain · 58% helix, 5% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B, A	Chloride channel protein 1	protein	599	58% helix, 5% strand	P35523

Pockets

20 pockets found on a 1 Å grid, 17 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	279	0.84	0.95	50	empty
2	308	0.84	0.94	64	empty
3	258	0.82	0.93	48	empty
4	210	0.81	0.94	36	empty
5	944	0.81	0.83	82	empty

Interfaces

1 interface between chains.

B–A · 2373 Å² buried · 13 hydrogen bonds · protein-protein

Compared structures

6QVU · CryoEM structure of the human ClC-1 chloride channel, low pH · the same entry in another collection · chain B against B, TM-score 1.00
P35523 · AlphaFold monomer V2.0 prediction for chloride channel protein 1 (P35523) · a predicted model of the same protein · chain B against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P35523
Elsewhere: RCSB PDB 6QVU · PDBe 6QVU · UniProt P35523

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