MolNFT v1 · #161993 · protein
Cryoem structure of the human clc-1 chloride channel, cbs state 3
6QVB · Chloride channel protein 1: “Cryoem structure of the human clc-1 chloride channel, cbs state 3”. Electron microscopy, 20 pockets (best druggability 0.82). MolNFT v1 #161993 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 6QVB
- Type
- protein
- Length
- 1,193 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chloride channel protein 1
- UniProt
- P35523
- Pockets
- 20 · best druggability 0.82
Structure
electron microscopy · 2 distinct chains · 59% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Chloride channel protein 1 | protein | 596 | 59% helix, 5% strand | P35523 |
| A | Chloride channel protein 1 | protein | 597 | 59% helix, 5% strand | P35523 |
Pockets
20 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 181 | 0.82 | 0.96 | 33 | empty |
| 2 | 751 | 0.82 | 0.85 | 89 | empty |
| 3 | 773 | 0.81 | 0.84 | 109 | empty |
| 4 | 179 | 0.78 | 0.93 | 41 | empty |
| 5 | 670 | 0.77 | 0.82 | 68 | empty |
Interfaces
1 interface between chains.
- B–A · 2336 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 6QVB · CryoEM structure of the human ClC-1 chloride channel, CBS state 3 · the same entry in another collection · chain B against B, TM-score 1.00
- P35523 · AlphaFold monomer V2.0 prediction for chloride channel protein 1 (P35523) · a predicted model of the same protein · chain A against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P35523
- Elsewhere: RCSB PDB 6QVB · PDBe 6QVB · UniProt P35523
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