MolNFT v1 · #161945 · protein
Crystal structure of an arabidopsis WD40 domain in complex with a flowering transcription factor homolog
6QTX · E3 ubiquitin-protein ligase COP1: “Crystal structure of an arabidopsis WD40 domain in complex with a flowering transcription factor homolog”. X-ray diffraction, 1 ligand (SO4), 2 pockets (best druggability 0.78). MolNFT v1 #161945…
- PDB
- 6QTX
- Type
- protein
- Length
- 313 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- E3 ubiquitin-protein ligase COP1; Zinc finger protein constans-like 3
- EC
- 2.3.2.27
- UniProt
- P43254, Q9SK53
- Ligands
- SO4
- Pockets
- 2 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 3% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | E3 ubiquitin-protein ligase COP1 (EC 2.3.2.27) | protein | 305 | 3% helix, 51% strand | P43254 |
| B | Zinc finger protein constans-like 3 | protein | 8 | 0% helix, 13% strand | Q9SK53 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 330 | 0.78 | 0.89 | 58 | SO4 |
| 2 | 51 | 0.32 | 0.77 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 506 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (oxidation).
Compared structures
- 6QTX · Crystal structure of an Arabidopsis WD40 domain in complex with a flowering transcription… · the same entry in another collection · chain A against A, TM-score 1.00
- P43254 · AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase COP1 (P43254) · a predicted model of the same protein · chain A against A, TM-score 1.00
- Q9SK53 · AlphaFold monomer V2.0 prediction for zinc finger protein constans- like 3 (Q9SK53) · a predicted model of the same protein · chain B against A, TM-score 0.47
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P43254
- Every structure of UniProt Q9SK53
- Elsewhere: RCSB PDB 6QTX · PDBe 6QTX · UniProt P43254 · UniProt Q9SK53
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