MolNFT v1 · #161940 · protein
Crystal structure of a mutant arabidopsis WD40 domain in complex with a photoreceptor
6QTS · E3 ubiquitin-protein ligase COP1: “Crystal structure of a mutant arabidopsis WD40 domain in complex with a photoreceptor”. X-ray diffraction, 1 ligand (SO4), 3 pockets (best druggability 0.73). MolNFT v1 #161940 on GenesisL1: 3D…
- PDB
- 6QTS
- Type
- protein
- Length
- 311 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- E3 ubiquitin-protein ligase COP1; Ultraviolet-B receptor UVR8
- EC
- 2.3.2.27
- UniProt
- P43254, Q9FN03
- Ligands
- SO4
- Pockets
- 3 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 2% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | E3 ubiquitin-protein ligase COP1 (EC 2.3.2.27) | protein | 304 | 2% helix, 51% strand | P43254 |
| B | Ultraviolet-B receptor UVR8 | protein | 7 | 0% helix, 14% strand | Q9FN03 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 295 | 0.73 | 0.86 | 38 | GOL |
| 2 | 50 | 0.66 | 0.96 | 24 | empty |
| 3 | 99 | 0.48 | 0.81 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 508 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 modified (oxidation, artifact).
Compared structures
- 6QTS · Crystal structure of a mutant Arabidopsis WD40 domain in complex with a photoreceptor · the same entry in another collection · chain A against A, TM-score 1.00
- P43254 · AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase COP1 (P43254) · a predicted model of the same protein · chain A against A, TM-score 1.00
- Q9FN03 · AlphaFold monomer V2.0 prediction for ultraviolet-B receptor UVR8 (Q9FN03) · a predicted model of the same protein · chain B against A, TM-score 0.54
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P43254
- Every structure of UniProt Q9FN03
- Elsewhere: RCSB PDB 6QTS · PDBe 6QTS · UniProt P43254 · UniProt Q9FN03
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.