MolNFT v1 · #161927 · protein
TSH2 domain of transcription elongation factor SPT6 complexed with tyrosine phosphorylated ctd
6QTC: “TSH2 domain of transcription elongation factor SPT6 complexed with tyrosine phosphorylated ctd”. Solution nmr, 1 pocket (best druggability 0.39). MolNFT v1 #161927 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6QTC
- Type
- protein
- Length
- 211 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TSH2 domain of transcription elongation factor SPT6; Tyrosine phosphorylated ctd
- UniProt
- Q6FLB1
- Pockets
- 1 · best druggability 0.39
Structure
solution nmr · 2 distinct chains · 27% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | TSH2 domain of transcription elongation factor SPT6 | protein | 195 | 29% helix, 30% strand | Q6FLB1 |
| B | Tyrosine phosphorylated ctd | protein | 16 | 0% helix, 0% strand | — |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 99 | 0.39 | 0.76 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 999 Ų buried · 22 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (phosphorylation).
Compared structures
- 6QTC · tSH2 domain of transcription elongation factor Spt6 complexed with tyrosine… · the same entry in another collection · chain A against A, TM-score 1.00
- Q6FLB1 · AlphaFold monomer V2.0 prediction for transcription elongation factor SPT6 (Q6FLB1) · a predicted model of the same protein · chain A against A, TM-score 0.82
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6FLB1
- Elsewhere: RCSB PDB 6QTC · PDBe 6QTC · UniProt Q6FLB1
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