MolNFT v1 · #161807 · protein
The structure of the cohesin head module elucidates the mechanism of ring opening
6QPQ · Structural maintenance of chromosomes PROTEIN,STRUCTURAL…: “The structure of the cohesin head module elucidates the mechanism of ring opening”. X-ray diffraction, 13 pockets (best druggability 0.72). MolNFT v1 #161807 on GenesisL1…
- PDB
- 6QPQ
- Type
- protein
- Length
- 957 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Structural maintenance of chromosomes PROTEIN,STRUCTURAL maintenance of chromosomes…
- UniProt
- G0SGH3, Q12158
- Pockets
- 13 · best druggability 0.72
Structure
x-ray diffraction · 4 distinct chains · 49% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Structural maintenance of chromosomes PROTEIN,STRUCTURAL maintenance of chromosomes protein | protein | 402 | 48% helix, 21% strand | G0SGH3 |
| B | Sister chromatid cohesion protein 1 | protein | 81 | 58% helix, 15% strand | Q12158 |
| C | Structural maintenance of chromosomes PROTEIN,STRUCTURAL maintenance of chromosomes protein | protein | 392 | 48% helix, 22% strand | G0SGH3 |
| D | Sister chromatid cohesion protein 1 | protein | 82 | 55% helix, 13% strand | Q12158 |
Pockets
13 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 830 | 0.72 | 0.77 | 94 | empty |
| 2 | 592 | 0.67 | 0.77 | 56 | empty |
| 3 | 106 | 0.53 | 0.83 | 22 | empty |
| 4 | 111 | 0.44 | 0.78 | 17 | empty |
| 5 | 119 | 0.44 | 0.77 | 17 | empty |
Interfaces
3 interfaces between chains.
- C–D · 1262 Ų buried · 16 hydrogen bonds · protein-protein
- A–B · 1208 Ų buried · 16 hydrogen bonds · protein-protein
- A–C · 594 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 6QPQ · The structure of the cohesin head module elucidates the mechanism of ring opening · the same entry in another collection · chain A against A, TM-score 1.00
- Q12158 · AlphaFold monomer V2.0 prediction for sister chromatid cohesion protein 1 (Q12158) · a predicted model of the same protein · chain B against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G0SGH3
- Every structure of UniProt Q12158
- Elsewhere: RCSB PDB 6QPQ · PDBe 6QPQ · UniProt G0SGH3 · UniProt Q12158
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