Research workbench
The structure of the cohesin head module elucidates the mechanism of ring opening
Analyse The structure of the cohesin head module elucidates the mechanism of ring… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6QPQ
- Type
- protein
- Length
- 957 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Structural maintenance of chromosomes PROTEIN,STRUCTURAL maintenance of chromosomes…
- UniProt
- G0SGH3, Q12158
- Pockets
- 13 · best druggability 0.72
Structure
x-ray diffraction · 4 distinct chains · 49% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Structural maintenance of chromosomes PROTEIN,STRUCTURAL maintenance of chromosomes protein | protein | 402 | 48% helix, 21% strand | G0SGH3 |
| B | Sister chromatid cohesion protein 1 | protein | 81 | 58% helix, 15% strand | Q12158 |
| C | Structural maintenance of chromosomes PROTEIN,STRUCTURAL maintenance of chromosomes protein | protein | 392 | 48% helix, 22% strand | G0SGH3 |
| D | Sister chromatid cohesion protein 1 | protein | 82 | 55% helix, 13% strand | Q12158 |
Pockets
13 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 830 | 0.72 | 0.77 | 94 | empty |
| 2 | 592 | 0.67 | 0.77 | 56 | empty |
| 3 | 106 | 0.53 | 0.83 | 22 | empty |
| 4 | 111 | 0.44 | 0.78 | 17 | empty |
| 5 | 119 | 0.44 | 0.77 | 17 | empty |
Interfaces
3 interfaces between chains.
- C–D · 1262 Ų buried · 16 hydrogen bonds · protein-protein
- A–B · 1208 Ų buried · 16 hydrogen bonds · protein-protein
- A–C · 594 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 6QPQ · The structure of the cohesin head module elucidates the mechanism of ring opening · the same entry in another collection · chain A against A, TM-score 1.00
- Q12158 · AlphaFold monomer V2.0 prediction for sister chromatid cohesion protein 1 (Q12158) · a predicted model of the same protein · chain B against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G0SGH3
- Every structure of UniProt Q12158
- Elsewhere: RCSB PDB 6QPQ · PDBe 6QPQ · UniProt G0SGH3 · UniProt Q12158
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