MolNFT v1 · #161605 · protein

Crystal structure of the third PDZ domain of psd-95 protein D332G mutant: space group I4122

6QJN · Disks large homolog 4: “Crystal structure of the third PDZ domain of psd-95 protein D332G mutant: space group I4122”. X-ray diffraction, 2 pockets (best druggability 0.61). MolNFT v1 #161605 on GenesisL1: 3D structure, binding sites…

PDB: 6QJN
Type: protein
Length: 184 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Disks large homolog 4
UniProt: P78352
Pockets: 2 · best druggability 0.61

Structure

x-ray diffraction · 2 distinct chains · 17% helix, 38% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Disks large homolog 4	protein	97	13% helix, 36% strand	P78352
B	Disks large homolog 4	protein	87	22% helix, 39% strand	P78352

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	419	0.61	0.76	34	empty
2	72	0.38	0.78	25	empty

Interfaces

1 interface between chains.

A–B · 573 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

6QJN · Crystal Structure of the third PDZ domain of PSD-95 protein D332G mutant: space group… · the same entry in another collection · chain A against A, TM-score 1.00
P78352 · AlphaFold monomer V2.0 prediction for disks large homolog 4 (P78352) · a predicted model of the same protein · chain B against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P78352
Elsewhere: RCSB PDB 6QJN · PDBe 6QJN · UniProt P78352

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