MolNFT v1 · #161473 · protein
Structure of human mcl-1 in complex with puma BH3 peptide
6QFM · Induced myeloid leukemia cell differentiation protein mcl- 1: “Structure of human mcl-1 in complex with puma BH3 peptide”. X-ray diffraction, 2 ligands (ZN, CL). MolNFT v1 #161473 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6QFM
- Type
- protein
- Length
- 159 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Induced myeloid leukemia cell differentiation protein mcl- 1; BCL-2-binding component 3
- UniProt
- Q07820, Q9BXH1
- Ligands
- ZN, CL
Structure
x-ray diffraction · 2 distinct chains · 84% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Induced myeloid leukemia cell differentiation protein mcl- 1 | protein | 140 | 83% helix, 0% strand | Q07820 |
| B | BCL-2-binding component 3 | protein | 19 | 89% helix, 0% strand | Q9BXH1 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
1 interface between chains.
- A–B · 927 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 6QFM · Structure of human Mcl-1 in complex with PUMA BH3 peptide · the same entry in another collection · chain A against A, TM-score 1.00
- Q9BXH1 · AlphaFold monomer V2.0 prediction for BCL-2-binding component 3, isoforms 1/2 (Q9BXH1) · a predicted model of the same protein · chain B against A, TM-score 0.72
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q07820
- Every structure of UniProt Q9BXH1
- Elsewhere: RCSB PDB 6QFM · PDBe 6QFM · UniProt Q07820 · UniProt Q9BXH1
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