MolNFT v1 · #161418 · protein
Structure of E.COLI rlmj in complex with a bisubstrate analogue (BA2)
6QE0 · Ribosomal RNA large subunit methyltransferase J: “Structure of E.COLI rlmj in complex with a bisubstrate analogue (BA2)”. X-ray diffraction, 1 ligand (HZ2), 2 pockets (best druggability 0.62). MolNFT v1 #161418 on GenesisL1: 3D…
- PDB
- 6QE0
- Type
- protein
- Length
- 278 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ribosomal RNA large subunit methyltransferase J
- EC
- 2.1.1.266
- UniProt
- A0A0G3KF30
- Ligands
- HZ2
- Pockets
- 2 · best druggability 0.62
Structure
x-ray diffraction · 1 distinct chain · 37% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ribosomal RNA large subunit methyltransferase J (EC 2.1.1.266) | protein | 278 | 37% helix, 20% strand | A0A0G3KF30 |
Ligands and binding sites
- HZ2 · (2~{S})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[2-[[9-[(2~{R},3~{R},4~{S},5~{R})-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]purin-6-yl]amino]ethyl]amino]-2-azanyl-butanoic acid · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 340 | 0.62 | 0.79 | 34 | HZ2 |
| 2 | 73 | 0.31 | 0.74 | 16 | empty |
Compared structures
- 6QE0 · Structure of E.coli RlmJ in complex with a bisubstrate analogue (BA2) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A0G3KF30
- Elsewhere: RCSB PDB 6QE0 · PDBe 6QE0 · UniProt A0A0G3KF30
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