Crystal structure of ULK1 in complexed with pf-03814735

Structure

x-ray diffraction · 2 distinct chains.

Ligands and binding sites

• 34W · N-{2-[(1S,4R)-6-{[4-(cyclobutylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-1,2,3,4-tetrahydro-1,4-epiminonaphthalen-9-yl]-2-oxoethyl}acetamide · ligand · 3 copies · chains A, B
• SO4 · Sulfate ion · ion · 6 copies · chains A, B
• EDO · 1,2-ethanediol · additive · 12 copies · chains A, B
• GOL · Glycerol · additive · 11 copies · chains A, B
• CIT · Citric acid · additive · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 6QAS · Crystal structure of ULK1 in complexed with PF-03814735 · the same entry in another collection · chain A against A, TM-score 1.00
• O75385 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase ULK1 (O75385) · a predicted model of the same protein · chain B against A, TM-score 0.97

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt O75385
• Elsewhere: RCSB PDB 6QAS · PDBe 6QAS · UniProt O75385