MolNFT v1 · #161271 · protein
Crystal structure of human arginase-1 at pH 7.0 in complex with abh
6Q92: “Crystal structure of human arginase-1 at pH 7.0 in complex with abh”. X-ray diffraction, 3 ligands (ABH, MN, NA), 3 pockets (best druggability 0.77). MolNFT v1 #161271 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6Q92
- Type
- protein
- Length
- 636 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Arginase-1
- EC
- 3.5.3.1
- UniProt
- P05089
- Ligands
- ABH, MN, NA
- Pockets
- 3 · best druggability 0.77
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Arginase-1 (EC 3.5.3.1) | protein | 318 | 43% helix, 17% strand | P05089 |
Ligands and binding sites
- ABH · 2(S)-amino-6-boronohexanoic acid · ligand · 2 copies · chains A, B
- MN · Manganese (II) ion · metal · 4 copies · chains A, B
- NA · Sodium ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 994 | 0.77 | 0.79 | 98 | ABH |
| 2 | 87 | 0.41 | 0.79 | 18 | ABH |
| 3 | 53 | 0.34 | 0.78 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 481 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P05089
- Elsewhere: RCSB PDB 6Q92 · PDBe 6Q92 · UniProt P05089
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