MolNFT v1 · #16122 · protein

Gelsolin domains 4-6 in active, actin free conformation identifies sites of regulatory calcium ions

1NPH: “Gelsolin domains 4-6 in active, actin free conformation identifies sites of regulatory calcium ions”. X-ray diffraction, 1 ligand (CA), 2 pockets (best druggability 0.59). MolNFT v1 #16122 on GenesisL1: 3D structure, binding sites…

PDB: 1NPH
Type: protein
Length: 323 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Gelsolin
UniProt: P13020
Ligands: CA
Pockets: 2 · best druggability 0.59

Structure

x-ray diffraction · 1 distinct chain · 24% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Gelsolin	protein	323	24% helix, 29% strand	P13020

Ligands and binding sites

CA · Calcium ion · metal · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	217	0.59	0.81	29	CA
2	242	0.58	0.79	30	empty

Compared structures

1NPH · Gelsolin Domains 4-6 in Active, Actin Free Conformation Identifies Sites of Regulatory… · the same entry in another collection · chain A against A, TM-score 1.00
P13020 · AlphaFold monomer V2.0 prediction for gelsolin (P13020) · a predicted model of the same protein · chain A against A, TM-score 0.63

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P13020
Elsewhere: RCSB PDB 1NPH · PDBe 1NPH · UniProt P13020

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