MolNFT v1 · #16104 · protein

T4 DNA polymerase fragment (residues 1-388) at 110K

1NOZ: “T4 DNA polymerase fragment (residues 1-388) at 110K”. X-ray diffraction, 10 pockets (best druggability 0.62). MolNFT v1 #16104 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1NOZ
Type: protein
Length: 692 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA polymerase
EC: 2.7.7.7
UniProt: P04415
Pockets: 10 · best druggability 0.62

Structure

x-ray diffraction · 1 distinct chain · 42% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	DNA polymerase (EC 2.7.7.7)	protein	346	42% helix, 18% strand	P04415

Pockets

10 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	364	0.62	0.78	27	empty
2	268	0.59	0.79	32	empty
3	105	0.58	0.85	21	empty
4	278	0.57	0.77	35	empty
5	208	0.55	0.78	31	empty

Interfaces

1 interface between chains.

A–B · 1451 Å² buried · 12 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

1NOZ · T4 DNA polymerase fragment (residues 1-388) at 110K · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P04415
Elsewhere: RCSB PDB 1NOZ · PDBe 1NOZ · UniProt P04415

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